protein

FNDC4 Protein, Human (HEK293, Fc)

HY-P76935

5 μg;10 μg;50 μg;100 μg

40;70;200;340 USD

FNDC4 Protein, Human (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

40;70;200;340 USD

The FNDC4 protein is an anti-inflammatory factor in the intestine and colon that regulates macrophages by downregulating pro-inflammatory gene expression and affecting phagocytosis. It does this by modulating key pathways associated with macrophage activation, in part through STAT3 activation and signaling. FNDC4 Protein, Human (HEK293, Fc) is the recombinant human-derived FNDC4 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of FNDC4 Protein, Human (HEK293, Fc) is 123 a.a., with molecular weight of ~50-60 KDa.

Human

FNDC4 protein functions as an anti-inflammatory factor in the intestine and colon, exerting its regulatory influence on macrophages. Through binding and interaction with macrophages, FNDC4 down-regulates the expression of pro-inflammatory genes, influencing essential macrophage functions such as phagocytosis. This anti-inflammatory effect is achieved by modulating key pathways associated with macrophage activation, in part through the activation and signaling of STAT3. The role of FNDC4 in dampening the immunological response, particularly in the context of colitis, underscores its potential significance as a molecular mediator in maintaining intestinal immune homeostasis.

Fibronectin type III domain-containing protein 4; Fibronectin type III repeat-containing protein 1; FRCP1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.