protein

FLRT2 Protein, Mouse (HEK293, His)

HY-P76934

2 μg;5 μg;10 μg;50 μg;100 μg;500 μg

30;54;75;170;270;755 USD

FLRT2 Protein, Mouse (HEK293, His)

proteins

HEK293

2 μg;5 μg;10 μg;50 μg;100 μg;500 μg

30;54;75;170;270;755 USD

The FLRT2 protein plays a key role in cell-cell adhesion, migration, and axonal guidance. Its interaction with ADGRL3 promotes cell-cell adhesion and promotes cortical neuronal migration through interaction with UNC5D. FLRT2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FLRT2 protein, expressed by HEK293 , with C-His labeled tag. The total length of FLRT2 Protein, Mouse (HEK293, His) is 504 a.a., with molecular weight of 60-80 kDa.

Mouse

FLRT2 protein exerts a crucial role in diverse cellular processes, including cell-cell adhesion, cell migration, and axon guidance. Its interaction with ADGRL3 and potentially other latrophilins expressed on adjacent cells facilitates cell-cell adhesion, while also playing a role in the migration of cortical neurons during brain development through interaction with UNC5D. In axon guidance, FLRT2 mediates growth cone collapse and exhibits a repulsive effect on neuron guidance, interacting with UNC5D and potentially other UNC-5 family members. Additionally, FLRT2 is implicated in fibroblast growth factor-mediated signaling cascades. Vital for normal cardiac basement membrane organization during embryogenesis, FLRT2 is also required for proper embryonic epicardium and heart morphogenesis. Through self-association via leucine-rich repeats, FLRT2 forms homooligomers and interacts with various partners, including FGFR1, FGFR2, ADGRL1/LPHN1, ADGRL3, UNC5D, UNC5B, and FN1.

Leucine-rich repeat transmembrane protein FLRT2; Flrt2; Kiaa0405

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.