protein

Draxin Protein, Human (HEK293, His)

HY-P76878

5 μg;10 μg;50 μg

60;100;280 USD

Draxin Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg

60;100;280 USD

The Draxin protein is critical in commissural development in the spinal cord and forebrain, serving as a chemical pulse guidance protein for commissural axons. It inhibits dorsal spinal cord neurite outgrowth and acts as a Wnt signaling antagonist by interacting with LRP6, inhibiting cytosolic β-catenin stabilization. Draxin Protein, Human (HEK293, His) is the recombinant human-derived Draxin protein, expressed by HEK293 , with C-His labeled tag.

Human

Draxin protein plays a crucial role in the development of spinal cord and forebrain commissures, acting as a chemorepulsive guidance protein for commissural axons. Its function extends to inhibiting or repelling neurite outgrowth from the dorsal spinal cord. Additionally, Draxin serves as an antagonist of the Wnt signaling pathway by inhibiting the stabilization of cytosolic beta-catenin (CTNNB1) through its interaction with LRP6. This multifaceted functionality underscores the significance of Draxin in guiding axonal development and modulating key signaling pathways during neural development, highlighting its intricate involvement in shaping the intricate architecture of the nervous system.

Dorsal inhibitory axon guidance protein; Neucrin; C1orf187

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.