protein

DEFA3/Defensin alpha 3 Protein, Human (HEK293, Fc)

HY-P76870

5 μg;10 μg;50 μg;100 μg

55;85;215;340 USD

DEFA3/Defensin alpha 3 Protein, Human (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

55;85;215;340 USD

The DEFA3/defensin alpha 3 protein is a potent effector in innate immunity against a variety of infectious agents, including bacteria, fungi, and viruses. It neutralizes bacterial toxins, such as Bacillus anthracis lethal factor and Staphylococcus aureus leukocidin, and plays a key role in blocking herpes simplex virus infection by preventing viral attachment. DEFA3/Defensin alpha 3 Protein, Human (HEK293, Fc) is the recombinant human-derived DEFA3/Defensin alpha 3 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of DEFA3/Defensin alpha 3 Protein, Human (HEK293, Fc) is 56 a.a., with molecular weight of ~36 KDa.

Human

The DEFA3/Defensin alpha 3 Protein functions as a potent effector molecule within the innate immune system, leveraging antibiotic-like properties to combat a broad spectrum of infectious agents, including bacteria, fungi, and viruses. Notably, it exhibits the capability to neutralize bacterial toxins such as B. anthracis lethal factor, Clostridium difficile cytotoxin B, and Staphylococcus aureus leukocidin. Additionally, DEFA3 plays a pivotal role in blocking herpes simplex virus infection by interacting with envelope glycoprotein B, preventing its attachment to heparan sulfate, a key receptor for viral attachment. This multifaceted immune activity underscores the protein's significance in host defense. DEFA3 operates as a dimer, showcasing its structural organization in executing its diverse antimicrobial functions.

Neutrophil defensin 3; HNP-3; Neutrophil defensin 2; HNP-2; DEF3

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.