protein

CLEC4D Protein, Human (HEK293, His)

HY-P76834

5 μg;10 μg;50 μg

68;115;320 USD

CLEC4D Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg

68;115;320 USD

The CLEC4D protein is a calcium-dependent lectin that functions as a pattern recognition receptor in the innate immune system, recognizing DAMPs and PAMPs on bacteria and fungi. It forms a functional complex with FCER1G in myeloid cells, triggering immune activation. CLEC4D Protein, Human (HEK293, His) is the recombinant human-derived CLEC4D protein, expressed by HEK293 , with N-His labeled tag. The total length of CLEC4D Protein, Human (HEK293, His) is 164 a.a., with molecular weight of 21-27 kDa.

Human

CLEC4D, a calcium-dependent lectin, operates as a pattern recognition receptor (PRR) in the innate immune system, discerning both damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) from bacteria and fungi. Recognizing alpha-mannans on C. albicans hyphae and mycobacterial trehalose 6,6'-dimycolate (TDM), CLEC4D forms a functional complex with the signaling adapter Fc receptor gamma chain/FCER1G, likely through its interaction with CLEC4E, in myeloid cells. Binding of TDM or C. albicans alpha-mannans to this receptor complex induces the phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, activating SYK, CARD9, and NF-kappa-B. This activation drives the maturation of antigen-presenting cells and influences antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. CLEC4D, when forming a heterodimer with CLEC6A, exhibits activity against fungal infections. Additionally, it functions as an endocytic receptor, suggesting a role in antigen uptake at the site of infection, either for antigen clearance or for processing and subsequent presentation to T-cells. The heterodimerization with CLEC4E and CLEC6A further highlights the dynamic and versatile nature of CLEC4D in immune surveillance and response mechanisms.

C-type lectin domain family 4 member D; CLEC-6; Dectin-3; CD368; CLECSF8

Greater than 90% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4

Shipping with dry ice.