protein

CD59a Protein, Mouse (HEK293, Fc)

HY-P76809

5 μg;10 μg;50 μg;100 μg

60;100;280;475 USD

CD59a Protein, Mouse (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

60;100;280;475 USD

CD59a Protein acts as a potent inhibitor of the complement membrane attack complex (MAC) by binding to C8 and/or C9 complements during MAC assembly. This interaction prevents the incorporation of multiple C9 copies, crucial for osmolytic pore formation. CD59a's regulatory role at the MAC assembly level safeguards cells, preventing uncontrolled osmolytic pore formation and protecting against complement-mediated damage. CD59a Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CD59a protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD59a Protein, Mouse (HEK293, Fc) is 72 a.a., with molecular weight of ~42 kDa.

Mouse

CD59a Protein emerges as a potent inhibitor of the complement membrane attack complex (MAC) action, functioning by binding to the C8 and/or C9 complements during the assembling MAC. Through this interaction, CD59a prevents the incorporation of multiple copies of C9 essential for the complete formation of the osmolytic pore. This regulatory role underscores the crucial contribution of CD59a in modulating the complement system, specifically at the level of MAC assembly, and serves as a pivotal safeguard mechanism against the uncontrolled formation of the osmolytic pore, ultimately protecting cells from potential complement-mediated damage.

CD59A glycoprotein; MAC-IP; MACIF; Protectin; CD59

Greater than 90% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.