protein

CD42c/GP1BB Protein, Human (HEK293, His)

HY-P76805

5 μg;10 μg;100 μg

160;275;1300 USD

CD42c/GP1BB Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;100 μg

160;275;1300 USD

CD42c/GP1BB protein, present on platelets, interacts with von Willebrand factor to form platelet plugs. It forms a heterodimer with GP1B beta subunits and associates with GP-IX, facilitating platelet adhesion and initiating thrombus formation. CD42c also interacts with TRAF4, potentially regulating cellular signaling pathways. CD42c/GP1BB Protein, Human (HEK293, His) is the recombinant human-derived CD42c/GP1BB protein, expressed by HEK293 , with C-His labeled tag.

Human

CD42c, also known as GP1BB, is a surface membrane protein on platelets crucial for the formation of platelet plugs through its interaction with von Willebrand factor, which is pre-bound to the subendothelium. The GP1BB protein forms a heterodimer with two disulfide-linked GP1B beta subunits and associates non-covalently with GP-IX. This intricate complex of GP1BB, GP1B alpha, and GP-IX plays a pivotal role in mediating platelet adhesion and initiating the process of thrombus formation. Additionally, CD42c has been identified to interact with TRAF4, suggesting potential regulatory roles in cellular signaling pathways.

Platelet glycoprotein Ib beta chain; GPIb-beta; CD42b-beta

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4 or PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.