protein

CD300LF Protein, Mouse (HEK293, Fc)

HY-P76793

5 μg;10 μg;50 μg;100 μg

60;100;280;475 USD

CD300LF Protein, Mouse (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

60;100;280;475 USD

The CD300LF protein, also known as DEC-205/CD205, directs antigens to the antigen-processing compartment. It inhibits myeloid cells and mast cells and promotes phagocytosis of apoptotic cells. CD300LF Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CD300LF protein, expressed by HEK293 , with C-mFc labeled tag. The total length of CD300LF Protein, Mouse (HEK293, Fc) is 174 a.a., with molecular weight of ~45.3 KDa.

Mouse

The CD300LF protein, also known as the DEC-205/CD205 protein, serves as an endocytic receptor responsible for directing captured antigens to a specialized antigen-processing compartment. It has been observed to function as an inhibitory receptor for myeloid cells and mast cells, positively regulating the phagocytosis of apoptotic cells through recognition and binding of phosphatidylserine (PS) ligands on the surface of apoptotic cells. CD300LF plays a crucial role in maintaining immune homeostasis by promoting macrophage-mediated efferocytosis while inhibiting dendritic cell-mediated efferocytosis. Additionally, it negatively regulates mast cell activation and allergic responses by binding to ceramide ligands. It may also act as a coreceptor for interleukin 4 (IL-4), enhancing IL-4 and IL-13-induced signaling. CD300LF negatively regulates Toll-like receptor signaling and inhibits osteoclast formation. Furthermore, it induces macrophage cell death upon engagement and acts as a functional receptor for murine norovirus (MNV), mediating viral entry and replication while determining MNV species tropism and rendering nonmurine mammalian cells susceptible to MNV infection.

CMRF35-like molecule 1; CLM-1; CD300 antigen-like family member F; CD300f

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.