protein

CD200R1 Protein, Cynomolgus (HEK293, His)

HY-P76780

5 μg;10 μg;50 μg

40;65;175 USD

CD200R1 Protein, Cynomolgus (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg

40;65;175 USD

CD200R1 Protein is an Ig superfamily transmembrane glycoprotein expressed on the surface of myeloid cells. CD200R1 Protein can also be induced in certain T-cell subsets. CD200R1 signaling inhibits the expression of proinflammatory molecules [1] . CD200R1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD200R1 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD200R1 Protein, Cynomolgus (HEK293, His) is 221 a.a., with molecular weight of 43-75 KDa.

Cynomolgus

CD200R1 is an Ig superfamily transmembrane glycoprotein expressed on the surface of myeloid cells; it can also be induced in certain T-cell subsets. CD200R1 interacts with CD200, which is also an Ig superfamily transmembrane glycoprotein, to down regulate myeloid cell functions. CD200 is expressed on the surface of a variety of cells including neurons, epithelial cells, endothelial cells, fibroblasts, lymphoid cells, and astrocytes. The regulation of CD200R1 signaling can occur by posttranslational modification-namely, phosphorylation of tyrosines in the CD200R1 cytoplasmic tail-or by the inducible expression or downregulation of either CD200R1 or CD200. The CD200:CD200R1 inhibitory signaling pathway has been implicated in playing a prominent role in limiting inflammation in a wide range of inflammatory diseases. CD200R1 signaling inhibits the expression of proinflammatory molecules including tumor necrosis factor, interferons, and inducible nitric oxide synthase in response to selected stimuli [1] .

Cell surface glycoprotein CD200 receptor 1; CD200R1; CD200R; CRTR2; MOX2R; OX2R

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.