protein

ALCAM/CD166 Protein, Cynomolgus (HEK293, His)

HY-P76777

5 μg;10 μg;50 μg;100 μg;500 μg

40;70;190;320;900 USD

ALCAM/CD166 Protein, Cynomolgus (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg

40;70;190;320;900 USD

ALCAM/CD166 Protein is a glycoprotein involved in homotypic and heterotypic cell adhesion. ALCAM/CD166 has emerged as a modulator of cancer progression, mainly by controlling cell proliferation, adhesion, migration and invasion [1] . ALCAM/CD166 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived ALCAM/CD166 protein, expressed by HEK293 , with C-His labeled tag. The total length of ALCAM/CD166 Protein, Cynomolgus (HEK293, His) is 499 a.a., with molecular weight of ~75-95 kDa.

Cynomolgus

Activated Leukocyte Cell Adhesion Molecule (ALCAM) or cluster of differentiation 166 (CD166) is a cell surface glycoprotein structurally related to the immunoglobulin superfamily molecules, initially identified on activated leukocytes. ALCAM is also found in epithelial cells, vascular endothelial cells, neurons, myeloid progenitors, hematopoietic stem cells, mesenchymal stem cells, bone marrow stromal cells, tumor cells and cancer stem cells. ALCAM can be proteolytically cleaved at the cell surface by metalloproteases, which generate shedding of its ectodomain. In normal physiology, ALCAM has been shown to modulate cell-cell interactions with lymphocytes as well as epithelial and endothelial cells. Besides cell adhesion, other ALCAM functions have been described such as angiogenesis, transmigration of monocytes, leukocyte intravasation across blood brain barrier, T cell activation, hematopoiesis, neurite extension, osteogenesis, and embryonic implantation in the uterus [1] .

ALCAM; CD166 antigen; Activated leukocyte cell adhesion molecule; MEMD

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.