CaMKII alpha/CAMK2A Protein, Human (sf9, GST) | MedChem Express LLC HY-P76761 product information

product summary

company name :

MedChem Express LLC

product type :

protein

product name :

CaMKII alpha/CAMK2A Protein, Human (sf9, GST)

catalog :

HY-P76761

quantity :

5 μg;10 μg;50 μg

price :

85;145;380 USD

more info or order :

MedChem Express LLC product webpage

product information

Catalog Number :

HY-P76761

Product Name :

CaMKII alpha/CAMK2A Protein, Human (sf9, GST)

Product Type :

proteins

Host Species :

Sf9 insect cells

Size :

5 μg;10 μg;50 μg

List Price :

85;145;380 USD

Product Description :

CaMKII α/CAMK2A protein functions autonomously upon Ca(2+)/calmodulin binding and autophosphorylation. CaMKII alpha/CAMK2A Protein, Human (sf9, GST) is the recombinant human-derived CaMKII alpha/CAMK2A protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of CaMKII alpha/CAMK2A Protein, Human (sf9, GST) is 478 a.a., with molecular weight of ~80 kDa.

SpeciesSummary :

Human

Background :

CaMKII alpha/CAMK2A protein, a calcium/calmodulin-dependent kinase, functions autonomously following Ca(2+)/calmodulin-binding and autophosphorylation, playing a crucial role in various cellular processes such as synaptic plasticity, neurotransmitter release, and long-term potentiation. As a member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR, thereby influencing excitatory synaptic transmission. CaMKII alpha also contributes to dendritic spine development and regulates the migration of developing neurons. Beyond these functions, it phosphorylates the transcription factor FOXO3 to activate its transcriptional activity and targets the transcription factor ETS1 in response to calcium signaling, decreasing ETS1 affinity for DNA. In response to interferon-gamma (IFN-gamma) stimulation, it catalyzes the phosphorylation of STAT1, thereby stimulating the JAK-STAT signaling pathway. Additionally, in response to interferon-beta (IFN-beta) stimulation, CaMKII alpha stimulates the JAK-STAT signaling pathway and acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity.

ALTnames :

Calcium/calmodulin-dependent protein kinase type II subunit alpha; CAMKA

Purity :

Greater than 85% as determined by reducing SDS-PAGE

Buffer :

Supplied as a 0.2 μm filtered solution of 50 mM Tris, 100 mM NaCl, 0.5 mM PMSF, 0.5 mM Reduced Glutathione, pH 8.0

Storage :

Shipping with dry ice.

more info or order :

MedChem Express LLC product webpage