protein

CHI3L1 Protein, Mouse (HEK293, His)

HY-P76702

5 μg;10 μg;50 μg;100 μg;500 μg

35;60;165;280;895 USD

CHI3L1 Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg

35;60;165;280;895 USD

The CHI3L1 protein is a carbohydrate-binding lectin with a preference for chitin that is involved in tissue remodeling and cellular adaptation to environmental changes. It is involved in Th2 inflammation, IL-13-induced inflammation, allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation, M2 macrophage differentiation and pathogenic intestinal bacterial invasion. CHI3L1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CHI3L1 protein, expressed by HEK293 , with C-10*His labeled tag.

Mouse

CHI3L1 Protein is a carbohydrate-binding lectin that exhibits a specific preference for chitin. Although it lacks chitinase activity, it plays crucial roles in tissue remodeling and enables cells to adapt and respond to environmental changes. It is involved in various processes, such as T-helper cell type 2 (Th2) inflammatory response, IL-13-induced inflammation, regulation of allergen sensitization, modulation of inflammatory cell apoptosis, dendritic cell accumulation, and promotion of M2 macrophage differentiation. Furthermore, it facilitates the invasion of pathogenic enteric bacteria into the colonic mucosa and lymphoid organs. In colonic epithelial cells, it mediates the activation of the AKT1 signaling pathway, leading to subsequent production of IL8. CHI3L1 also regulates antibacterial responses in the lung by enhancing macrophage bacterial killing, controlling bacterial dissemination, and promoting host tolerance. Additionally, it plays a role in regulating hyperoxia-induced injury, inflammation, and epithelial apoptosis in the lung. It exists as a monomer.

Chitinase-3-Like protein 1; 39 kDa Synovial Protein; CGP-39; GP-39; hCGP-39; YKL-40

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.