protein

ULBP4/RAET1E Protein, Human (HEK293, His)

HY-P76691

5 μg;10 μg;50 μg;100 μg

35;60;165;280 USD

ULBP4/RAET1E Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

35;60;165;280 USD

ULBP4/RAET1E Protein crucially activates natural killer cell cytotoxicity by binding to and activating the KLRK1/NKG2D receptor. This interaction mediates cytotoxic responses, contributing to receptor activation and facilitating the recognition and targeting of marked cells for elimination. ULBP4/RAET1E's engagement with KLRK1/NKG2D underscores its significance in immune response regulation and natural killer cell activity modulation. ULBP4/RAET1E Protein, Human (HEK293, His) is the recombinant human-derived ULBP4/RAET1E protein, expressed by HEK293 , with C-His labeled tag. The total length of ULBP4/RAET1E Protein, Human (HEK293, His) is 195 a.a., with molecular weight of ~35-40 kDa.

Human

The ULBP4/RAET1E protein plays a crucial role in natural killer cell cytotoxicity by serving as a ligand that binds to and activates the KLRK1/NKG2D receptor. This interaction between ULBP4/RAET1E and KLRK1/NKG2D is pivotal in mediating the cytotoxic responses of natural killer cells. Through its binding affinity with KLRK1/NKG2D, ULBP4/RAET1E contributes to the activation of this receptor, facilitating the recognition and targeting of cells marked for elimination. The engagement of ULBP4/RAET1E with KLRK1/NKG2D underscores its significance in the regulation of immune responses and the modulation of natural killer cell activity.

Retinoic acid early transcript 1E; NKG2D ligand 4; LETAL; N2DL4

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.