protein

TNFAIP8 Protein, Human (His)

HY-P76682

5 μg;10 μg;50 μg

46;75;215 USD

TNFAIP8 Protein, Human (His)

proteins

E. coli

5 μg;10 μg;50 μg

46;75;215 USD

TNFAIP8 Protein functions as a negative regulator of apoptosis, inhibiting caspase-8 activity and suppressing TNF-mediated apoptosis without affecting procaspase-8 processing.This control prevents BID cleavage and subsequent caspase-3 activation, contributing to cellular survival mechanisms.TNFAIP8's role highlights its potential significance in apoptosis regulation and its implications for tumor development.TNFAIP8 Protein, Human (His) is the recombinant human-derived TNFAIP8 protein, expressed by E.coli , with N-His labeled tag.

Human

TNFAIP8 Protein serves as a negative regulator of apoptosis and is implicated in tumor progression. Its functional role involves the suppression of TNF-mediated apoptosis through the inhibition of caspase-8 activity, while not affecting the processing of procaspase-8. This, in turn, leads to the prevention of BID cleavage and the subsequent activation of caspase-3. By exerting control over key components in the apoptotic pathway, TNFAIP8 contributes to cellular survival mechanisms, emphasizing its potential significance in the context of apoptosis regulation and its implications for tumor development.

Tumor necrosis factor alpha-induced protein 8; MDC-3.13; NDED; SCC-S2; TNF-induced protein GG2-1

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.0, 10% Glycerol, 10% trehalose, 0.02% Tween80.

Room temperature in continental US; may vary elsewhere.