TM4SF2/TSPAN7 Protein, Rat (HEK293, His) | MedChem Express LLC HY-P76677 product information

product summary

company name :

MedChem Express LLC

product type :

protein

product name :

TM4SF2/TSPAN7 Protein, Rat (HEK293, His)

catalog :

HY-P76677

quantity :

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

price :

40;70;200;340;950;1615 USD

more info or order :

MedChem Express LLC product webpage

product information

Catalog Number :

HY-P76677

Product Name :

TM4SF2/TSPAN7 Protein, Rat (HEK293, His)

Product Type :

proteins

Host Species :

HEK293

Size :

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

List Price :

40;70;200;340;950;1615 USD

Product Description :

TM4SF2/TSPAN7 protein is a highly expressed tetraspanin that is involved in synaptic transmission, neuronal morphogenesis, DCs, and osteoblast morphogenesis. Additionally, it plays a key role in tumorigenesis, promotion, and metastasis. TM4SF2/TSPAN7 Protein, Rat (HEK293, His) is the recombinant rat-derived TM4SF2/TSPAN7 protein, expressed by HEK293 , with N-His labeled tag. The total length of TM4SF2/TSPAN7 Protein, Rat (HEK293, His) is 101 a.a., with molecular weight of ~13.9 kDa.

SpeciesSummary :

Rat

Background :

TM4SF2/TSPAN7 Protein regulates the transport of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, participates in synaptic transmission, neuronal morphogenesis, and DCs and osteoblasts morphogenesis. M4SF2/TSPAN7 Protein participates in the spinal maturation of cultured hippocampal neurons through direct interaction with PICK1 [1] . Overexpression of TM4SF2/TSPAN7 protein promotes the formation of filopodia and dendritic spines in embryonic rat hippocampal neuronal cultures. Silencing of TM4SF2/TSPAN7 protein reduces head size and spine stability as well as AMPA receptor currents. [2] . TM4SF2/TSPAN7 protein promotes the epithelial-mesenchymal transition (EMT) process by reducing the expression of E-cadherin and vimentin, thereby promoting the proliferation and migration of non-small cell lung cancer (NSCLC) cells [3] TM4SF2/TSPAN7 Protein induces apoptosis and cell cycle arrest in bladder cancer cell lines. TM4SF2/TSPAN7 Protein inhibits the growth of bladder cancer cells by activating Bax, cleaved Caspase-3 and PTEN and inactivating Bcl-2, p-PI3K and p-AKT [4] .

ALTnames :

Tetraspanin-7; Tspan-7; CD231; Mxs1; Tm4sf2

Purity :

Greater than 85% as determined by reducing SDS-PAGE

Buffer :

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage :

Room temperature in continental US; may vary elsewhere.

more info or order :

MedChem Express LLC product webpage