protein

TCPTP Protein, Mouse (sf9, His)

HY-P76669

50 μg;100 μg

500;850 USD

TCPTP Protein, Mouse (sf9, His)

proteins

Sf9 insect cells

50 μg;100 μg

500;850 USD

TCPTP is a non-receptor tyrosine-specific phosphatase that regulates multiple signaling pathways by dephosphorylating proteins such as INSR, EGFR, CSF1R, PDGFR, JAK, Src kinase and STAT.TCPTP acts in the nucleus and cytoplasm to regulate hematopoiesis, inflammation, cell proliferation, differentiation, and glucose homeostasis.TCPTP Protein, Mouse (sf9, His) is the recombinant mouse-derived TCPTP protein, expressed by Sf9 insect cells , with N-His labeled tag.

Mouse

TCPTP, a non-receptor type tyrosine-specific phosphatase, exerts its regulatory influence by dephosphorylating a spectrum of proteins involved in various signaling pathways. This includes receptor protein tyrosine kinases like INSR, EGFR, CSF1R, and PDGFR, as well as non-receptor protein tyrosine kinases such as JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3, and STAT6. Operating both in the nucleus and cytoplasm, TCPTP negatively modulates crucial biological processes, spanning hematopoiesis, inflammatory response, cell proliferation, and differentiation, as well as glucose homeostasis. It plays a pivotal role in immune system development, impacting T-cell receptor signaling, macrophage differentiation, and cytokine-mediated pathways. Additionally, TCPTP participates in the negative regulation of growth factor signaling, exemplified by its role in anchorage-dependent control of EGF-stimulated cell growth. Activated by integrin ITGA1/ITGB1, TCPTP dephosphorylates EGFR, PDGFRB, and SRC, exerting regulatory effects on their respective signaling pathways. Notably, TCPTP extends its influence to glucose homeostasis by negatively regulating insulin receptor signaling and controlling gluconeogenesis. Moreover, it may exhibit DNA-binding capabilities.

Tyrosine-protein phosphatase non-receptor type 2; MPTP; PTPN2

Greater than 90% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 8.0, 20% Glycerol, 0.1 mM TCEP. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.