protein

IL-27R alpha/TCCR Protein, Mouse (HEK293, His)

HY-P76668

50 μg;100 μg

385;650 USD

IL-27R alpha/TCCR Protein, Mouse (HEK293, His)

proteins

HEK293

50 μg;100 μg

385;650 USD

IL-27R alpha(Interleukin 27 receptor alpha) is a subunit of the interleukin-27 receptor, an inflammatory cytokine that possesses extensive immunological functions. IL-27R alphacan be used as a natural IL-27 antagonist [1] . IL-27R alpha/TCCR Protein, Mouse (HEK293, His) is a recombinant protein with a His label that consists of 482 amino acids (G29-K510) and is produced by HEK293 cells.

Mouse

IL-27Rα is specific for IL-27 and is primarily expressed on the cell surface of inflammatory cells, including T, B, and NK lymphocytes, neutrophils, monocytes, and mast cells, although it is found at lower levels in macrophages, hepatocytes, keratinocytes, and endothelial cells [2] . The amino acid sequence of human IL-27R alpha protein has low homology for mouse IL-27R alpha protein. IL-27Rα (WSX-1) and gp130 compose the IL-27 receptor-signaling complex. Binding of IL-27 to its heterodimeric receptor complex leads to the intracellular recruitment and activation of the Janus kinase (JAK)/STAT-1 and STAT-3 pathways, suppress the expression of inflammatory cytokines [3] . IL-27R alpha is a class I cytokine receptor with homology to gp130 of IL-6R and to IL-12R families. IL-27R alpha can be used as a natural IL-27 antagonist [1] . IL-27R alpha can be used as an independent prognostic aGVHD biomarker [4] . IL-27/IL-27R alpha also plays an important role in the down-regulation of airway hyper-reactivity and lung inflammation during the development of allergic asthma through its suppressive effect on cytokine production [5] . IL-27/IL-27RA signaling can suppress the expression of inflammatory cytokines, IL-6 and IL-8, induced by LPS stimulation, leading to phosphorylation of STAT1 and STAT3 [6] .

Interleukin-27 receptor subunit alpha; IL-27R-alpha; TCCR; WSX-1; IL-27RA

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.