protein

L-Selectin/CD62L Protein, Rat (HEK293, His)

HY-P76638

5 μg;10 μg;50 μg;100 μg

35;50;140;240 USD

L-Selectin/CD62L Protein, Rat (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

35;50;140;240 USD

L-selectin/CD62L is a calcium-dependent lectin that binds adjacent glycoproteins to allow lymphocyte adhesion to endothelial cells in peripheral lymph nodes. This encourages leukocytes to bind and roll within endothelial tissue. L-Selectin/CD62L Protein, Rat (HEK293, His) is the recombinant rat-derived L-Selectin/CD62L protein, expressed by HEK293 , with C-His labeled tag.

Rat

L-Selectin/CD62L, a calcium-dependent lectin, plays a pivotal role in cell adhesion by binding to glycoproteins on adjacent cells. It facilitates the adherence of lymphocytes to the endothelial cells of high endothelial venules in peripheral lymph nodes, promoting the initial tethering and rolling of leukocytes within endothelial tissues. The recruitment and rolling of leukocytes are dependent on interactions with SELPLG/PSGL1 and PODXL2, where the sialyl Lewis X glycan modification of SELPLG and PODXL2, along with tyrosine sulfation modifications of SELPLG, are essential. Notably, the sulfation on 'Tyr-51' of SELPLG emerges as a critical factor for the binding of L-Selectin, underscoring its importance in facilitating cellular interactions and adhesive processes.

L-selectin; LAM-1; LECAM1; TQ1; gp90-MEL; CD62L; SELL; LNHR; LYAM1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.