protein

BID Protein, Human

HY-P7662

10 μg;50 μg

86;240 USD

BID Protein, Human

proteins

E. coli

10 μg;50 μg

86;240 USD

BID Protein, Human expresses in E. coli. The BH3-only protein BID, a pro-apoptotic member of the Bcl-2 family, was initially discovered through binding to both pro-apoptotic Bax and anti-apoptotic Bcl-2. BID is activated in the BCL-2-regulated or mitochondrial apoptosis pathway and acts as a switch between the extrinsic and intrinsic cell death pathways [1] .

Human

During apoptosis, Bid can be cleaved not only by caspase-8 during death receptor apoptotic signaling, but also by other caspases, granzyme B, calpains and cathepsins. Protease-cleaved Bid migrates to mitochondria where it induces permeabilization of the outer mitochondrial membrane that is dependent on the pro-apoptotic proteins Bax and/or Bak, and thus Bid acts as a sentinel for protease-mediated death signals [1] .

rHuBID; BH3-Interacting Domain Death Agonist; BID

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filter solution of 20 mM PB, 100 mM KCl, pH 7.4.

Shipping with dry ice.