protein

RSPO2/R-Spondin 2 Protein, Human (HEK293, Fc)

HY-P76582

5 μg;10 μg;50 μg

109;185;520 USD

RSPO2/R-Spondin 2 Protein, Human (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg

109;185;520 USD

RSPO2 is a key activator of the canonical Wnt pathway, serving as a ligand for LGR4-6 receptors and forming a complex with phosphorylated LRP6 and Frizzled receptors. This interaction activates the canonical Wnt pathway and increases target gene expression. RSPO2/R-Spondin 2 Protein, Human (HEK293, Fc) is the recombinant human-derived RSPO2/R-Spondin 2 protein, expressed by HEK293 , with C-hFc labeled tag.

Human

RSPO2, a pivotal activator of the canonical Wnt signaling pathway, functions as a ligand for LGR4-6 receptors, particularly LGR4, LGR5, or LGR6. Upon binding to these receptors, the resultant complex associates with phosphorylated LRP6 and frizzled receptors, which are activated by extracellular Wnt receptors. This interaction triggers the canonical Wnt signaling pathway, leading to the increased expression of target genes. Additionally, RSPO2 serves as a regulator of both the canonical Wnt/beta-catenin-dependent pathway and the non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, a crucial regulator of the Wnt signaling pathway. Notably, during embryonic development, RSPO2 plays a crucial role in limb specification by amplifying the Wnt signaling pathway independently of LGR4-6 receptors. This amplification occurs, possibly by RSPO2 acting as a direct antagonistic ligand to RNF43 and ZNRF3, thereby governing the number of limbs an embryo should form. RSPO2 interacts with WNT1, binds heparin, and interacts with LGR4, LGR5, and LGR6. Furthermore, RSPO2 engages with the E3 ubiquitin ligases RNF43 and ZNRF3, indicating its involvement in the intricate regulatory network of the Wnt signaling pathway.

R-spondin-2; Roof plate-specific spondin-2; RSPO2

Greater than 90% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of Histidine, Arginine, 120 mM NaCl, 0.02% Tween 80, 5% sucrose, pH 6.0.

Shipping with dry ice.