protein

RGMB Protein, Human (HEK293, His)

HY-P76573

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

46;79;220;374;970;1550 USD

RGMB Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

46;79;220;374;970;1550 USD

The RGMB protein is a member of the repulsion guidance molecule (RGM) family and plays a critical role in the developing nervous system by enhancing bone morphogenetic protein (BMP) signaling. As a BMP coreceptor, RGMB promotes neuronal adhesion and may inhibit neurite outgrowth. RGMB Protein, Human (HEK293, His) is the recombinant human-derived RGMB protein, expressed by HEK293 , with C-His labeled tag. The total length of RGMB Protein, Human (HEK293, His) is 368 a.a., with molecular weight of ~42 kDa.

Human

RGMB Protein, a member of the repulsive guidance molecule (RGM) family, plays a crucial role in shaping the developing nervous system by contributing to its patterning. Functioning as a bone morphogenetic protein (BMP) coreceptor, RGMB enhances BMP signaling, highlighting its involvement in pivotal cellular processes. Additionally, RGMB promotes neuronal adhesion and may exert an inhibitory effect on neurite outgrowth. Existing as a homooligomer, RGMB interacts with DRGX and forms functional complexes with BMP2, BMP4, ACVR1, BMPR1A, BMPR1B, and ACVR2B, orchestrating a network of interactions critical for cellular signaling. Notably, its complex with the receptor NEO1/neogenin adopts a heterotetrameric structure with a 2:2 stoichiometry, where RGM molecules act as staples, bringing two NEO1 receptors together without direct self-interaction. This unique arrangement facilitates downstream signaling activation via the RhoA pathway, emphasizing RGMB's multifaceted role in orchestrating intricate molecular events during neural development.

Repulsive guidance molecule B; RGM-B

Greater than 90% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.