protein

PTPMT1 Protein, Human (His)

HY-P76556

5 μg;10 μg

60;100 USD

PTPMT1 Protein, Human (His)

proteins

E. coli

5 μg;10 μg

60;100 USD

The PTPMT1 protein is a lipid phosphatase that critically regulates cellular lipid metabolism by dephosphorylating phosphatidylglycerolphosphate (PGP) to form phosphatidylglycerol (PG). This step is critical for the biosynthesis of cardiolipin, a key mitochondrial phospholipid that regulates membrane integrity and mitochondrial activity. PTPMT1 Protein, Human (His) is the recombinant human-derived PTPMT1 protein, expressed by E. coli , with N-His labeled tag.

Human

PTPMT1 protein functions as a lipid phosphatase with a key role in cellular lipid metabolism. It catalyzes the dephosphorylation of phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG), a crucial step in the biosynthetic pathway of cardiolipin—an essential mitochondrial phospholipid that regulates membrane integrity and mitochondrial activities. Beyond its lipid-related functions, PTPMT1 exhibits phosphatase activity toward phosphoprotein substrates, particularly involved in the dephosphorylation of mitochondrial proteins. This activity is crucial for ATP production and plays a role in the regulation of insulin secretion in pancreatic beta cells. Additionally, PTPMT1 is implicated in preventing intrinsic apoptosis, likely by regulating mitochondrial membrane integrity.

Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1; PTPMT1; MOSP; PLIP

Greater than 90% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.