protein

PSAP/Prosaposin Protein, Human (HEK293, His)

HY-P76553

5 μg;10 μg;20 μg;50 μg;100 μg;500 μg;1 mg

45;70;110;210;340;950;1600 USD

PSAP/Prosaposin Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;20 μg;50 μg;100 μg;500 μg;1 mg

45;70;110;210;340;950;1600 USD

Frizzled-7 protein is a transmembrane receptor that plays a crucial role in the Wnt signaling pathway. It is involved in cellular processes such as cell proliferation, differentiation, and migration. PSAP/Prosaposin Protein, Human (HEK293, His) is the recombinant human-derived PSAP/Prosaposin protein, expressed by HEK293 , with C-10*His labeled tag. The total length of PSAP/Prosaposin Protein, Human (HEK293, His) is 508 a.a., with molecular weight of 60-85 kDa.

Human

The PSAP/Prosaposin Protein, encoded by this gene, is a highly conserved preproprotein that undergoes proteolytic processing to yield four main cleavage products—saposins A, B, C, and D. Each domain of the precursor protein, approximately 80 amino acid residues long, exhibits nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D primarily localize to the lysosomal compartment, where they play a crucial role in facilitating the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists in both secretory and integral membrane forms and possesses neurotrophic activities. Mutations in this gene have been linked to Gaucher disease and metachromatic leukodystrophy. Alternative splicing yields multiple transcript variants, with at least one encoding an isoform that undergoes proteolytic processing. The gene displays ubiquitous expression, with elevated levels detected in the spleen (RPKM 523.6), gall bladder (RPKM 491.5), and 25 other tissues, emphasizing its essential role across various physiological contexts in multiple organs.

Proactivator polypeptide; Saposin-A; PSAP; GLBA; SAP1

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.