product summary
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company name :
MedChem Express LLC
product type :
protein
product name :
PIN1 Protein, Human
catalog :
HY-P76546
quantity :
10 μg;50 μg;100 μg
price :
90;245;390 USD
more info or order :
product information
Catalog Number :
HY-P76546
Product Name :
PIN1 Protein, Human
Product Type :
proteins
Host Species :
E. coli
Size :
10 μg;50 μg;100 μg
List Price :
90;245;390 USD
Product Description :
The PIN1 protein is a peptidyl-prolyl cis/trans isomerase that complexly regulates multiple cellular processes by binding and isomerizing phosphorylated Ser/Thr-Pro motifs. This molecular switch induces conformational changes in phosphorylated proteins that affect mitosis, kinase activity, oncogene transactivation, centrosome amplification, and cell transformation. PIN1 Protein, Human is the recombinant human-derived PIN1 protein, expressed by E. coli , with tag free. The total length of PIN1 Protein, Human is 163 a.a., with molecular weight of ~18 kDa.
SpeciesSummary :
Human
Background :
PIN1 Protein, a peptidyl-prolyl cis/trans isomerase (PPIase), intricately participates in multiple cellular processes by binding to and isomerizing specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. This molecular switch induces conformational changes in phosphorylated proteins, influencing diverse cellular pathways. With a preference for acidic residues N-terminally to the proline bond, PIN1 regulates mitosis by interacting with NIMA, attenuating its mitosis-promoting activity, and down-regulating the kinase activity of BTK. It transactivates oncogenes, induces centrosome amplification, chromosome instability, and cell transformation. Moreover, PIN1 is crucial for the dephosphorylation and recycling of RAF1, binding and targeting PML and BCL6 for degradation, and acting as a regulator of the JNK cascade by disrupting FBXW7 dimerization. PIN1's involvement extends to DNA repair processes, where it influences the balance between error-prone non-homologous end joining (NHEJ) and error-free homologous recombination (HR). During IL33-induced lung inflammation, PIN1 catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, contributing to IRAK3 stabilization, nuclear translocation, and the expression of pro-inflammatory genes in dendritic cells.
ALTnames :
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Rotamase Pin1; PIN1
Purity :
Greater than 95% as determined by reducing SDS-PAGE
Buffer :
Supplied as a 0.2 μm filtered solution of 50 mM Tris, 10% Glycerol, pH 8.0.
Storage :
Shipping with dry ice
more info or order :
company information
MedChem Express LLC
18 Wilkinson Way, Princeton, NJ 08540
sales@medchemexpress.com
http://www.medchemexpress.com609-228-6898
headquarters: USA