protein

LRPAP1 Protein, Human (HEK293, His)

HY-P76478

5 μg;10 μg;50 μg

95;160;420 USD

LRPAP1 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg

95;160;420 USD

The LRPAP1 protein serves as a molecular chaperone for LDL receptor-related proteins and regulates ligand binding throughout the secretory pathway. It transiently interacts with the LRP1/α-2-macroglobulin receptor chain, reducing ligand binding. LRPAP1 Protein, Human (HEK293, His) is the recombinant human-derived LRPAP1 protein, expressed by HEK293 , with C-His labeled tag. The total length of LRPAP1 Protein, Human (HEK293, His) is 323 a.a., with molecular weight of ~43 KDa.

Human

LRPAP1 protein serves as a molecular chaperone for LDL receptor-related proteins, contributing to the regulation of their ligand binding activity throughout the secretory pathway. Notably, LRPAP1 engages in transient interactions with the LRP1/alpha-2-macroglobulin receptor heavy and light chains, coinciding with a reduction in ligand binding by the receptor. Additionally, LRPAP1 forms interactions with LRP2/glycoprotein 330, LDLR, and SORL1, with diverse outcomes ranging from internalization and degradation to modulating ligand binding. The intricate network of interactions underscores the multifaceted role of LRPAP1 in orchestrating the function and trafficking of LDL receptor-related proteins.

Alpha-2-macroglobulin receptor-associated protein; Alpha-2-MRAP; RAP; A2MRAP

Greater than 90% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Shipping with dry ice.