product summary
Loading...
company name :
MedChem Express LLC
product type :
protein
product name :
BAG-2 Protein, Human (His)
catalog :
HY-P7647
quantity :
10 μg;50 μg
price :
165;496 USD
more info or order :
product information
Catalog Number :
HY-P7647
Product Name :
BAG-2 Protein, Human (His)
Product Type :
proteins
Host Species :
E. coli
Size :
10 μg;50 μg
List Price :
165;496 USD
Product Description :
BAG2 Protein, Human (His) promotes tumorigenesis through enhancing mutant p53 protein levels and function. BAG2 is a target of the c-Myc gene and is involved in cellular senescence via the p21CIP1 pathway [1] [2] .
SpeciesSummary :
Human
Background :
BAG2, a protein of Bcl-2 associated athanogene (BAG) family, promotes mutp53 accumulation and GOF in tumors. Mechanistically, BAG2 binds to mutp53 and translocates to the nucleus to inhibit the MDM2-mutp53 interaction, and MDM2-mediated ubiquitination and degradation of mutp53. Thus, BAG2 promotes mutp53 accumulation and GOF in tumor growth, metastasis and chemoresistance. BAG2 is frequently overexpressed in tumors [1] .
ALTnames :
rHuBAG2, His; BAG Family Molecular Chaperone Regulator 2; BAG-2; Bcl-2-Associated Athanogene 2; BAG2
Purity :
Greater than 90% as determined by reducing SDS-PAGE.
Buffer :
Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 1 mM EDTA, 1 mM DTT, 10% Glycerol, pH 8.0.
Storage :
Shipping with dry ice.
more info or order :
company information
MedChem Express LLC
18 Wilkinson Way, Princeton, NJ 08540
sales@medchemexpress.com
http://www.medchemexpress.com609-228-6898
headquarters: USA