protein

Kirrel1/NEPH1 Protein, Human (HEK293, His)

HY-P76468

50 μg;100 μg

385;650 USD

Kirrel1/NEPH1 Protein, Human (HEK293, His)

proteins

HEK293

50 μg;100 μg

385;650 USD

The Kirrel1/NEPH1 protein is essential for the normal function of the glomerular filtration barrier in the kidney, maintaining stable podocyte structure through finger-like foot processes and gap septal cell-cell junctions. As a signaling molecule, it requires TEC kinase to fully activate the transcription factor AP-1. Kirrel1/NEPH1 Protein, Human (HEK293, His) is the recombinant human-derived Kirrel1/NEPH1 protein, expressed by HEK293 , with C-His labeled tag.

Human

Kirrel1/NEPH1 Protein is crucial for the proper function of the glomerular filtration barrier in the kidneys. It plays a vital role in maintaining a stable podocyte architecture by facilitating the interdigitating foot processes connected by specialized cell-cell junctions called the slit diaphragm. This protein acts as a signaling molecule and requires the presence of TEC kinases to fully activate the transcription factor AP-1. Kirrel1/NEPH1 interacts with TJP1/ZO-1 and NPHS2/podocin, and its interaction with NPHS1/nephrin relies on Kirrel1/NEPH1 glycosylation. It forms homodimers through its Ig-like domains and, when tyrosine-phosphorylated, it interacts with GRB2.

Kin of IRRE-like protein 1; Kin of irregular chiasm-like protein 1; Nephrin-like protein 1; Kirrel1; Neph1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.