protein

Kallikrein-7 Protein, Human (HEK293, His)

HY-P76466

50 μg

450 USD

Kallikrein-7 Protein, Human (HEK293, His)

proteins

HEK293

50 μg

450 USD

Kallikrein-7 is a serine protease with chymotrypsin-like activity that plays a role in intercellular proteolysis, leading to epidermal exfoliation. It is involved in cancer invasion and metastasis, and elevated expression is associated with poor prognosis and cancer progression. Kallikrein-7 Protein, Human (HEK293, His) is the recombinant human-derived Kallikrein-7 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Kallikrein-7 Protein, Human (HEK293, His) is 231 a.a., with molecular weight of 30-33 KDa.

Human

Kallikrein-7, a member of the kallikrein subfamily of serine proteases, exhibits chymotrypsin-like activity and participates in the proteolysis of intercellular cohesive structures preceding desquamation, the shedding of the outermost epidermal layer. This enzyme's diverse physiological functions extend to its involvement in cancer-related processes, including invasion and metastasis. Elevated expression of the Kallikrein-7 gene is associated with an unfavorable prognosis and the progression of various cancer types. Polymorphisms in this gene may contribute to the development of atopic dermatitis. Situated within a gene cluster on chromosome 19, this gene has multiple alternatively spliced transcript variants, reflecting its complexity and involvement in various cellular processes. With biased expression observed in skin (RPKM 68.1) and esophagus (RPKM 25.3), Kallikrein-7 emerges as a multifaceted protease with implications in both normal physiology and disease states.

Kallikrein-7; Serine protease 6; hSCCE; KLK7; PRSS6; SCCE

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.