protein

IFN-alpha 10/IFNA10 Protein, Human (HEK293, His)

HY-P76457

2 μg;10 μg;50 μg;100 μg

30;80;190;290 USD

IFN-alpha 10/IFNA10 Protein, Human (HEK293, His)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg

30;80;190;290 USD

IFN-alpha 10 (IFNA10), belongs to type I interferon family, is produced by macrophages with antiviral activities [1] . IFN-alpha 10/IFNA10 Protein, Human (HEK293, His) contains 189 a.a. (M1-D189), produced in HEK293 cells with a C-terminal His-tag.

Human

IFN-alpha 10 (IFNA10; IFN-α10), belongs to the alpha/beta interferon (IFN) family, is produced by the macrophages with antiviral activities [1] . Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively [2] . Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Interferon alpha (IFNa) shows significant biological activity in various cancers, paticularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia [3] . IFNα-10 involves in JAK/STAT signaling pathway with strong signaling effect (EC 50 =0.3 nM), is identified as potent regulators that reduces both CTLA4 and FOXP3 without affecting cell viability. Therefore, regulatory T cells (Tregs) as the key cells regulating peripheral autoreactive T lymphocytes, IFNα-10 regulates Treg functional states and destabilises Treg [4] .

Interferon alpha-10; Interferon alpha-6L; Interferon alpha-C; LeIF C

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.