protein

LILRB4/CD85k/ILT3 Protein, Human (237a.a, HEK293, Fc)

HY-P76441

5 μg;10 μg;50 μg;100 μg;500 μg

60;105;295;500;1600 USD

LILRB4/CD85k/ILT3 Protein, Human (237a.a, HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg

60;105;295;500;1600 USD

LILRB4 is a leukocyte immunoglobulin-like receptor located on chromosome 19q13.4 and has an extracellular immunoglobulin domain, a transmembrane domain and a cytoplasmic ITIM. It is expressed on immune cells, interacts with class I MHC, and inhibits the stimulation of immune responses. LILRB4/CD85k/ILT3 Protein, Human (237a.a, HEK293, Fc) is the recombinant human-derived LILRB4/CD85k/ILT3 protein, expressed by HEK293 , with C-hFc labeled tag.

Human

LILRB4, a member of the leukocyte immunoglobulin-like receptor (LIR) family, is situated in a gene cluster on chromosomal region 19q13.4. Falling within the subfamily B class of LIR receptors, it contains multiple extracellular immunoglobulin domains, a transmembrane domain, and cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). This receptor, expressed on immune cells, interacts with MHC class I molecules on antigen-presenting cells, triggering a negative signal that inhibits immune response stimulation. Additionally, LILRB4 plays a role in antigen capture and presentation, potentially influencing inflammatory responses and cytotoxicity to modulate the immune response and prevent autoreactivity. The gene exhibits broad expression across various tissues, including the appendix (RPKM 9.2), lymph nodes (RPKM 8.1), and 17 other tissues. Multiple transcript variants encoding diverse isoforms have been identified for this gene.

Leukocyte immunoglobulin-like receptor subfamily B member 4; CD85k; Lilrb4; Gp49b

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.