protein

ILKAP/PP2C delta Protein, Human (HEK293, His)

HY-P76438

2 μg;5 μg;10 μg;50 μg

30;50;75;215 USD

ILKAP/PP2C delta Protein, Human (HEK293, His)

proteins

HEK293

2 μg;5 μg;10 μg;50 μg

30;50;75;215 USD

The ILKAP/PP2C delta protein is a key phosphatase that potentially regulates cell cycle progression by dephosphorylating substrates essential for proliferation. It selectively binds to ILK and regulates cell adhesion and growth factor signaling. ILKAP/PP2C delta Protein, Human (HEK293, His) is the recombinant human-derived ILKAP/PP2C delta protein, expressed by HEK293 , with C-His labeled tag. The total length of ILKAP/PP2C delta Protein, Human (HEK293, His) is 392 a.a.

Human

ILKAP/PP2C delta protein emerges as a key phosphatase with potential implications in the regulation of cell cycle progression by dephosphorylating substrates crucial for cell proliferation. This protein selectively associates with integrin-linked kinase (ILK), exerting modulatory effects on cell adhesion and growth factor signaling. ILKAP/PP2C delta specifically inhibits the ILK-GSK3B signaling axis, suggesting a role in restraining the pathway's activity. Such inhibition may play a critical role in impeding oncogenic transformation, emphasizing ILKAP/PP2C delta's significance as a potential tumor suppressor. The intricate interplay between ILKAP/PP2C delta, ILK, and downstream signaling pathways underscores its regulatory role in fundamental cellular processes, with implications for both cell cycle dynamics and oncogenic transformation control.

Integrin-linked kinase-associated serine/threonine phosphatase 2C; ILKAP; PP2C delta

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 8.0, 8% trehalose.

Room temperature in continental US; may vary elsewhere.