protein

IL-1F10/IL-38 Protein, Human (P.pastoris, His)

HY-P76427

5 μg;10 μg;50 μg;100 μg

72;120;340;580 USD

IL-1F10/IL-38 Protein, Human (P.pastoris, His)

proteins

P. pastoris

5 μg;10 μg;50 μg;100 μg

72;120;340;580 USD

IL-1F10/IL-38 protein is an immunomodulatory cytokine that indirectly regulates cytokine production. It reduces IL22 and IL17A production in T cells exposed to heat-killed Candida albicans and inhibits IL36G-induced IL8 production in peripheral blood mononuclear cells. IL-1F10/IL-38 Protein, Human (P.pastoris, His) is the recombinant human-derived IL-1F10/IL-38 protein, expressed by P. pastoris , with C-His labeled tag. The total length of IL-1F10/IL-38 Protein, Human (P.pastoris, His) is 152 a.a., with molecular weight of 20-23 KDa.

Human

IL-1F10/IL-38 Protein is an immunomodulatory cytokine that does not directly induce cytokine production. Instead, it plays a regulatory role by reducing IL22 and IL17A production in T-cells following exposure to heat-killed Candida albicans. Additionally, it inhibits IL36G-induced IL8 production in peripheral blood mononuclear cells. Interestingly, IL-1F10/IL-38 Protein enhances IL6 production in dendritic cells stimulated by bacterial lipopolysaccharides (LPS). It acts as a ligand for IL-36R/IL1RL2 and interacts with the cargo receptor TMED10, facilitating translocation from the cytoplasm to the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and subsequent secretion.

Interleukin-1 Family Member 10; IL-1F10; IL-1HY2; IL-1 Theta; IL1F10; FIL1T; IL-38

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.