protein

IL-17A Protein, Marmoset

HY-P76418

2 μg;10 μg;50 μg;100 μg;500 μg

35;100;280;450;1250 USD

IL-17A Protein, Marmoset

proteins

E. coli

2 μg;10 μg;50 μg;100 μg;500 μg

35;100;280;450;1250 USD

IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases [1] [2] . IL-17A Protein, Marmoset is a recombinant marmoset IL-17A protein is expressed in E. coli. It consists of 134 amino acids (I20-A153).

Marmoset

Interleukin-17A (IL-17A), also known as CTLA-8, belongs to the IL-17 cytokine family. IL-17A is expressed in memory Th17 cells and is a product of memory CD4 + T cells. IL-17A is also produced by a wide variety of immune cells, including CD8 + T cells, γδT cells, natural killer T (NKT) cells, monocytes, and neutrophils [1] [2] [3] . The rhesus macaque IL-17A shares 90.20% amino acid sequence identity with human and 63.40% identity with mouse. IL-17A plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides (defensins and S100 proteins), cytokines (IL-6, G-CSF, and GM-CSF), chemokines (CXCL1, CXCL5, IL-8, CCL2, and CCL7), and matrix metalloproteinases (MMP1, MMP3, and MMP13). IL-17A is detrimental in viral infection through promoting neutrophilic inflammation. IL-17A is a homodimeric cytokine and shares similar biological activities with IL-17F. IL-17A binds to IL-17RA with high affinity, and IL-17RA is required for the biological activity of IL-17A. In tumorigenesis, IL-17A recruits myeloid derived suppressor cells (MDSCs) to dampen anti-tumor immunity. IL-17A also enhances tumor growth in vivo through the induction of IL-6 [1] [2] . IL-17A can be used for the research of autoimmune diseases, infection and cancer [1] [4] .

Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL17A; CTLA8; IL17

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4, 5% trehalose, 5% mannitol and 0.01% Tween80.

Room temperature in continental US; may vary elsewhere.