protein

IGSF3 Protein, Human (HEK293, His)

HY-P76412

5 μg;10 μg;50 μg;100 μg

55;90;280;450 USD

IGSF3 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

55;90;280;450 USD

IGSF3 Protein, an immunoglobulin-like superfamily member, has a Glu-Trp-Ile (EWI) motif in extracellular region. IGSF3 is a developmentally regulated protein that controls neuronal morphogenesis. IGSF3 controls the differentiation of granule cells, axonal growth and branching. IGSF3 is a novel regulator of neuronal morphogenesis that might function through interactions with multiple partners including the tetraspanin TSPAN7. IGSF3 functions as a tumor promoter and induces hepatocellular carcinoma (HCC) cancer cell growth and invasion by acting through the NF-κB signaling pathways [1] [2] . IGSF3 Protein, Human (HEK293, His) is the recombinant human-derived IGSF3 protein, expressed by HEK293 , with C-His labeled tag. The total length of IGSF3 Protein, Human (HEK293, His) is 1105 a.a., with molecular weight of 130-150 KDa.

Human

IGSF3 is a membrane protein expressed in a neuron specific- and time-dependent manner during brain development. In the developing brain, IGSF3 is in a complex with the tetraspanin TSPAN7, a membrane protein mutated in several forms of X-linked intellectual disabilities [1] . IGSF3, situated on chromosome 1p13.1, is part of the immunoglobulin (Ig) superfamily. IGSF3 promotes the growth of HCC in vivo in a xenograft tumor model. IGSF3 enhances cell cycle progression, cell growth, migration, and invasion of HCC cell lines. Reduction in expression of IGSF3 through knockdown significantly reduces the levels of p-NF-κB/NF-κB and p-IKBα/IKBα, and overexpression of IGSF3 has the opposite result [2] .

Immunoglobulin superfamily member 3; IgSF3; Glu-Trp-Ile EWI motif-containing protein 3; EWI-3

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.