protein

IFN-alpha 14/IFNA14 Protein, Mouse (HEK293, His)

HY-P76401

2 μg;5 μg;10 μg;50 μg

35;65;100;280 USD

IFN-alpha 14/IFNA14 Protein, Mouse (HEK293, His)

proteins

HEK293

2 μg;5 μg;10 μg;50 μg

35;65;100;280 USD

IFN-alpha 14 (IFNA14), belongs to type I interferon family, is produced by macrophages with antiviral activities [1] . IFN-alpha 14/IFNA14 Protein, Mouse (HEK293, His) contains 166 a.a. (C24-K189), produced in HEK293 cells with a C-terminal His-tag.

Mouse

IFN-alpha 14 (IFNA14; IFN-α14), belongs to the alpha/beta interferon (IFN) family, is produced by the macrophages with antiviral activities [1] . Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively [2] . Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Interferon alpha (IFNa) shows significant biological activity in various cancers, paticularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia [3] . IFN-alpha 14 involves in JAK/STAT signaling pathway, is identified as potent regulators that reduces both CTLA4 and FOXP3. Therefore, regulatory T cells (Tregs) as the key cells regulating peripheral autoreactive T lymphocytes, IFNα-14 regulates Treg functional states and destabilises Treg [4] . IFN-alpha14 is a new gene found in tissues of uninfected mice, also found to lack N-glycosylation and have its expression induced in response to viral infection in contrast to IFN-alpha 13 [5] .

Interferon alpha-14; Interferon alpha-H; LeIF H; Interferon lambda-2-H; IFNA14

Greater than 90% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Shipping with dry ice.