protein

HIST2H2BE Protein, Human

HY-P76381

50 μg

650 USD

HIST2H2BE Protein, Human

proteins

E. coli

50 μg

650 USD

The HIST2H2BE protein is a core component of nucleosomes, key structures in chromatin organization that wrap and compact DNA, controlling its accessibility to cellular machinery based on DNA templates. This integral role of histones, including HIST2H2BE, extends to transcriptional regulation, DNA repair, DNA replication, and chromosomal stability. HIST2H2BE Protein, Human is the recombinant human-derived HIST2H2BE protein, expressed by E. coli , with tag free. The total length of HIST2H2BE Protein, Human is 126 a.a., with molecular weight of ~16 KDa.

Human

Histone HIST2H2BE is a core component of the nucleosome, serving a pivotal role in wrapping and compacting DNA into chromatin. This compaction restricts DNA accessibility to cellular machineries, impacting crucial processes such as transcription regulation, DNA repair, DNA replication, and chromosomal stability. The regulation of DNA accessibility involves a complex interplay of post-translational modifications known as the histone code, along with nucleosome remodeling. Beyond its chromatin-associated functions, HIST2H2BE exhibits broad antibacterial activity, suggesting potential contributions to the formation of the functional antimicrobial barrier in the colonic epithelium. Additionally, this histone may play a role in the bactericidal activity of amniotic fluid, highlighting its multifaceted significance in both chromatin dynamics and host defense mechanisms against microbial threats.

Histone H2B type 2-E; Histone H2B-GL105; H2B/q; H2BC21; H2BFQ

Greater than 95% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of PBS,pH 7.4.

Shipping with dry ice