protein

FSTL3 Protein, Mouse (HEK293, His)

HY-P76349

5 μg;10 μg;50 μg;100 μg

60;100;280;480 USD

FSTL3 Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

60;100;280;480 USD

In its secreted form, the FSTL3 protein acts as a binder and antagonist to TGF-β family members, inhibiting cell signaling induced by activin A, activin B, BMP2, and MSTN. It plays a role in bone formation, inhibition of osteoclast differentiation, hematopoiesis, and enhanced hematopoietic progenitor cell adhesion. FSTL3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FSTL3 protein, expressed by HEK293 , with C-His labeled tag. The total length of FSTL3 Protein, Mouse (HEK293, His) is 233 a.a., with molecular weight of 35-40 KDa.

Mouse

The FSTL3 Protein, in its secreted form, acts as a binding and antagonizing agent for members of the TGF-beta family, such as activin, BMP2, and MSTN. It effectively inhibits cellular signaling induced by activin A, activin B, BMP2, and MSTN, with a higher efficacy observed for activin A. FSTL3 plays a role in bone formation by inhibiting osteoclast differentiation and contributes to hematopoiesis by influencing the differentiation of hemopoietic progenitor cells and enhancing their adhesion to fibronectin. Moreover, it appears to play a role in the adhesion of hematopoietic precursor cells to the bone marrow stroma. The nuclear form of FSTL3 likely participates in transcriptional regulation through its interaction with MLLT10. Additionally, FSTL3 interacts with INHBA, INHBB, FN1, ADAM12, and MSTN, further highlighting its diverse molecular interactions and multifaceted functional roles.

Follistatin-related protein 3; Follistatin-like protein 3; FLRG

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.