protein

FAM20B Protein, Human (HEK293, Fc)

HY-P76326

5 μg;10 μg;50 μg;100 μg

45;70;200;340 USD

FAM20B Protein, Human (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

45;70;200;340 USD

The FAM20B protein plays a key role in regulating mature glycosaminoglycan (GAG) chains by catalyzing xylose 2-O-phosphorylation in the glycosaminoglycan-protein linking region of the proteoglycan. This process is critical for the synthesis of sulfated GAGs (such as heparan sulfate and chondroitin sulfate) on the common GAG-protein linking region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of the core protein. FAM20B Protein, Human (HEK293, Fc) is the recombinant human-derived FAM20B protein, expressed by HEK293 , with N-hFc labeled tag. The total length of FAM20B Protein, Human (HEK293, Fc) is 379 a.a., with molecular weight of ~75-80 KDa.

Human

The FAM20B protein assumes a pivotal role in the regulation of mature glycosaminoglycan (GAG) chains by catalyzing the 2-O-phosphorylation of xylose within the glycosaminoglycan-protein linkage region of proteoglycans. This process is integral to the synthesis of sulfated GAGs, including heparan sulfate and chondroitin sulfate, on the common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins. The stepwise addition of monosaccharide residues by specific glycosyltransferases forms this linkage region, where xylose 2-O-phosphorylation plays a regulatory role in the catalytic activity of B3GAT3 (GlcAT-I). B3GAT3 completes the precursor tetrasaccharide of GAG-protein linkage regions, serving as a foundation for the subsequent synthesis of the repeating disaccharide region. FAM20B's involvement in xylose 2-O-phosphorylation highlights its crucial contribution to the precise regulation of GAG chain assembly and the intricate orchestration of glycosaminoglycan structures.

Glycosaminoglycan xylosylkinase; Xylose kinase; KIAA0475

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.