protein

ECSIT Protein, Human (His)

HY-P76311

5 μg;10 μg;50 μg;100 μg

45;75;200;340 USD

ECSIT Protein, Human (His)

proteins

E. coli

5 μg;10 μg;50 μg;100 μg

45;75;200;340 USD

ECSIT protein is an adapter protein in Toll-like receptors, IL-1, and antiviral signaling that crucially activates NF-kappa-B by complexing with TRAF6 and TAK1/MAP3K7, leading to TAK1/MAP3K7 activation and subsequent IKK activation. Ubiquitinated ECSIT interacts with RELA and NFKB1 and translocates to induce NF-kappa-B-dependent gene expression. ECSIT Protein, Human (His) is the recombinant human-derived ECSIT protein, expressed by E. coli , with N-His labeled tag.

Human

ECSIT protein functions as an adapter protein in various signaling pathways, including Toll-like receptors (TLRs), interleukin-1 (IL-1) pathways, and innate antiviral induction signaling. It plays a pivotal role in activating NF-kappa-B by forming a signal complex with TRAF6 and TAK1/MAP3K7, ultimately leading to the activation of TAK1/MAP3K7 and subsequent IKK activation. Upon ubiquitination, ECSIT interacts with dissociated RELA and NFKB1 proteins, translocating to the nucleus and inducing NF-kappa-B-dependent gene expression. In the context of the innate antiviral immune response, ECSIT bridges pattern recognition receptors RIGI and MDA5/IFIT1 to the MAVS complex at the mitochondrion. Additionally, ECSIT promotes the proteolytic activation of MAP3K1, participates in the BMP signaling pathway, and is essential for normal embryonic development. Furthermore, as part of the MCIA complex, ECSIT contributes to the assembly of mitochondrial complex I.

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Protein SITPEC; ECSIT

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCL, 300 mM NaCl, pH 8.0.

Room temperature in continental US; may vary elsewhere.