protein

B2M/Beta-2-microglobulin Protein, Human (His)

HY-P7625

2 μg;5 μg;10 μg;50 μg;100 μg

30;46;60;120;204 USD

B2M/Beta-2-microglobulin Protein, Human (His)

proteins

E. coli

2 μg;5 μg;10 μg;50 μg;100 μg

30;46;60;120;204 USD

B2M/Beta-2-microglobulin Protein is a secreted protein found on the outside of the cell membrane. B2M/Beta-2-microglobulin Protein is a crucial component of MHC class I molecules, essential for presenting tumor antigens to T cells. B2M/Beta-2-microglobulin Protein is a systemic pro-aging factor that can impair cognitive function and neurogenesis. B2M/Beta-2-microglobulin Protein, Human (His) is a recombinant human Beta-2-microglobulin protein with a His tag, expressed in E. coli [1] [2] .

Human

B2M/Beta-2-microglobulin Protein is a low molecular weight protein that shares sequence homology with immunoglobulins. It is found in almost all nucleated cells and most body fluids, including serum, urine, and synovial fluid [2] . B2M/Beta-2-microglobulin Protein shows about 70% amino acid sequence similarity with mouse protein, and both are located on homologous chromosomes. The secondary structure of this protein consists of seven β chains, which are connected by a single disulfide bond to form two β sheets, displaying the classic β sandwich structure typical of immunoglobulin domains [3] . B2M/Beta-2-microglobulin Protein is expressed at a constant level in many cells and can induce the expression of IL-6, IL-8, and IL-10 in various cell types, regulate the expression of hormones/growth factors, and coordinate interactions between cytokines and their receptors [2] . B2M/Beta-2-microglobulin Protein can interact with MHC I or similar molecules to stabilize their tertiary structure, and it plays a significant role in regulating functions related to the survival, proliferation, apoptosis, and even metastasis of cancer cells [2] . B2M/Beta-2-microglobulin Protein is closely related to diseases such as acute and chronic inflammation, liver/kidney dysfunction, viral infections, and tumors [2] .

rHuBeta-2-microglobulin, His; Beta-2-Microglobulin; B2M

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, PH 7.4 or PBS, 300 mM NaCl, pH 7 or 20 mM PB, 300 mM NaCl, pH 7.4, 10% trehalose and 0.02% Tween80 or PBS, pH 7.4, 8% trehalose.

Room temperature in continental US; may vary elsewhere.