protein

Azurocidin Protein, Human (HEK293, His)

HY-P7624

5 μg;10 μg;50 μg;100 μg;250 μg;500 μg

40;65;175;300;700;1200 USD

Azurocidin Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;250 μg;500 μg

40;65;175;300;700;1200 USD

Azurocidin Protein, Human (HEK293, His), a recombinant human Azurocidin produced in HEK293 cells, has a His tag. Azurocidin is a protein that is mobilized rapidly from emigrating polymorphonuclear leukocytes (PMN). Azurocidin serves as an important mediator during the initiation of the immune response [1] .

Human

Azurocidin, released from PMN secretory vesicles or primary granules, acts as a chemoattractant and activator of monocyte and macrophages. The functional consequence is enhancement of cytokine release and bacterial phagocytosis, allowing for a more efficient bacterial clearance. Leukocyte activation by Azurocidin is mediated via β2-integrins, and Azurocidin-induced chemotaxis is dependent on formyl-peptide receptors. In addition, Azurocidin activates endothelial cells leading to vascular leakage and edema formation. For these reasons, targeting azurocidin release and its actions may have therapeutic potential in inflammatory disease conditions [1] .

rHuAzurocidin, His; Azurocidin; Cationic Antimicrobial Protein CAP37; Heparin-Binding Protein

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against 20 mM HEPES, 150 mM NaCl, pH 7.5 or PBS, pH 7.4, 8% trehalose.

Room temperature in continental US; may vary elsewhere.