protein

TCblR/CD320 Protein, Rat (HEK293, Fc)

HY-P76226

5 μg;10 μg;50 μg;100 μg;500 μg

35;60;170;290;810 USD

TCblR/CD320 Protein, Rat (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg

35;60;170;290;810 USD

The TCblR/CD320 protein is a receptor for cobalamin-saturated transcobalamin (TCbl) and is critical for cobalamin uptake and can influence cell physiology. At the plasma membrane, it is expressed on follicular dendritic cells (FDC), where it helps interact with germinal center B cells and promotes immune responses. TCblR/CD320 Protein, Rat (HEK293, Fc) is the recombinant rat-derived TCblR/CD320 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TCblR/CD320 Protein, Rat (HEK293, Fc) is 182 a.a., with molecular weight of ~47.3 KDa.

Rat

TCblR/CD320 Protein, as the receptor for transcobalamin saturated with cobalamin (TCbl), assumes a crucial role in cobalamin uptake, demonstrating its significance in cellular physiology. Positioned on the plasma membrane, this receptor is notably expressed on follicular dendritic cells (FDC), facilitating interaction with germinal center B cells and contributing to the intricate network of immune responses. Functioning as a costimulator, TCblR promotes B cell responses to antigenic stimuli, thereby fostering B cell differentiation and proliferation. Specifically, it plays a vital role in the differentiation of germinal center-B (GC-B) cells into memory B-cells and plasma cells (PC) through collaborative interactions with T-cells and FDC. Notably, CD320 enhances the proliferation of PC precursors generated by IL-10, showcasing its multifaceted involvement in immune modulation. The interaction of TCblR with TCN2 further highlights its role in cobalamin homeostasis and cellular processes.

CD320 antigen; 8D6 antigen; FDC-signaling molecule 8D6; FDC-SM-8D6; Transcobalamin receptor

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.