protein

Basigin/CD147 Protein, Cynomolgus (HEK293, His)

HY-P76202

5 μg;10 μg;50 μg;100 μg

37;60;170;270 USD

Basigin/CD147 Protein, Cynomolgus (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

37;60;170;270 USD

Basigin, also called CD147 or EMMPRIN, is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily with homology to both the immunoglobulin V domain and major histocompatibility complex class II antigen 尾-chain. Basigin is the receptor for cyclophilins, S100A9 and platelet glycoprotein VI. Basigin tightly associates with monocarboxylate transporters and is essential for their cell surface translocation and activities [1] [2] [3] . Basigin/CD147 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Basigin/CD147 protein, expressed by HEK293 , with C-His labeled tag.

Cynomolgus

Basigin has isoforms; the common form (basigin or basigin-2) has two immunoglobulin domains, and the extended form (basigin-1) has three. Basigin-1 serves as the receptor for the rod-derived cone viability factor. In the same membrane plane, basigin also associates with other proteins including GLUT1, CD44 and CD98. The carbohydrate portion of basigin is recognized by lectins, such as galectin-3 and E-selectin. These molecular recognitions form the basis for the role of basigin in the transport of nutrients, migration of inflammatory leukocytes and induction of matrix metalloproteinases. Basigin is important in vision, spermatogenesis and other physiological phenomena, and plays significant roles in the pathogenesis of numerous diseases, including cancer. Basigin is also the receptor for an invasive protein RH5, which is present in malaria parasites [1] . The CD147 gene, designated BSG for basigin, is located on chromosome 19p13.3 and encodes a 29 kD protein, though migration on SDS-PAGE usually occurs between 35–65 kD, depending on the degree of glycosylation. Three glycosylation sites have been identified within the CD147 Ig like domains: two within the membrane proximal Ig domain and one within the distal Ig domain [3] .

Basigin; HT7 antigen; Membrane glycoprotein gp42; Bsg

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.