protein

CD146/MCAM Protein, Mouse (HEK293, His)

HY-P76201

5 μg;10 μg;50 μg;100 μg

35;60;170;290 USD

CD146/MCAM Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

35;60;170;290 USD

The CD146/MCAM protein is a multifunctional adhesion regulator that plays a crucial role in maintaining endothelial monolayer adhesion in vascular tissue. Its expression is associated with promoting interactions between melanoma cells and vascular components, potentially enhancing hematogenous spread of tumors. CD146/MCAM Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD146/MCAM protein, expressed by HEK293 , with C-His labeled tag. The total length of CD146/MCAM Protein, Mouse (HEK293, His) is 540 a.a., with molecular weight of 90-100 KDa.

Mouse

CD146/MCAM, a versatile protein, assumes a crucial role in cell adhesion and the cohesion of the endothelial monolayer at intercellular junctions within vascular tissue. Its expression holds significance in facilitating interactions between melanoma cells and cellular components of the vascular system, potentially augmenting the hematogeneous spread of tumors. Beyond its involvement in tumor biology, CD146/MCAM is postulated to function as an adhesion molecule during embryonic development, particularly in neural crest cells. Acting as a surface receptor, it triggers tyrosine phosphorylation events involving FYN and PTK2/FAK1, accompanied by a transient increase in intracellular calcium concentration (By similarity).

Cell surface glycoprotein MUC18; Gicerin; CD146; Muc18

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.