protein

ATG5 Protein, Human

HY-P7620

10 μg;50 μg

115;345 USD

ATG5 Protein, Human

proteins

E. coli

10 μg;50 μg

115;345 USD

ATG5 is an important participant in the formation of autophagy vesicles and binds to ATG12 through a ubiquitin-like system, which is critical for the lipidation of ATG8 family proteins. It plays a crucial role in mitochondrial quality control, affects cell longevity, and is critical for lymphocyte development, antigen processing, axonal morphology maintenance, adipocyte differentiation, primary ciliogenesis, and apoptotic processes. ATG5 Protein, Human is the recombinant human-derived ATG5 protein, expressed by E. coli , with tag free. The total length of ATG5 Protein, Human is 275 a.a., with molecular weight of ~33.0 kDa.

Human

ATG5, a key participant in autophagic vesicle formation, undergoes conjugation with ATG12 through a ubiquitin-like system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme. The resulting ATG12-ATG5 conjugate serves as an E3-like enzyme essential for lipidation of ATG8 family proteins and their association with vesicle membranes. Beyond its role in autophagy, ATG5 contributes to mitochondrial quality control post-oxidative damage, impacting cellular longevity. It plays a critical role in lymphocyte development, vital for the survival and proliferation of both B and T lymphocytes, and is necessary for optimal antigen processing and presentation for MHC II. Additionally, ATG5 is involved in maintaining axon morphology, normal adipocyte differentiation, and promoting primary ciliogenesis through autophagic pathways. Moreover, it may play a crucial role in apoptotic processes, occurring downstream of caspase activity, and participates in IFN-gamma-induced autophagic cell death through interaction with FADD.

rHuATG5; Autophagy protein 5; APG5-like; Apoptosis-specific protein; APG5L; ASP; ATG5;

Greater than 90% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filter solution of 20 mM Tris, 0.2 M NaCl,1 mM DTT, 40%glycerol, pH 8.0 .

Shipping with dry ice.