protein

CES2/carboxylesterase 2 Protein, Human (HEK293,C-His)

HY-P76192

50 μg

520 USD

CES2/carboxylesterase 2 Protein, Human (HEK293,C-His)

proteins

HEK293

50 μg

520 USD

The CES2 protein plays a crucial role in detoxifying xenobiotics and activating ester and amide prodrugs. It has high catalytic efficiency, especially in the hydrolysis of substances such as cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine. CES2/carboxylesterase 2 Protein, Human (HEK293,C-His) is the recombinant human-derived CES2/carboxylesterase 2 protein, expressed by HEK293 , with C-His labeled tag. The total length of CES2/carboxylesterase 2 Protein, Human (HEK293,C-His) is 533 a.a., with molecular weight of ~60.4 KDa.

Human

The CES2/Carboxylesterase 2 Protein plays a crucial role in the detoxification of xenobiotics and the activation of ester and amide prodrugs. It exhibits high catalytic efficiency in the hydrolysis of various compounds, including cocaine, 4-methylumbelliferyl acetate, heroin, and 6-monoacetylmorphine. Additionally, CES2 hydrolyzes aspirin, substrates with large alcohol groups and small acyl groups, as well as endogenous lipids such as triacylglycerol. Notably, it is involved in the conversion of monoacylglycerides to free fatty acids and glycerol. Furthermore, CES2 demonstrates activity in the hydrolysis of 2-arachidonoylglycerol and prostaglandins, highlighting its versatility in enzymatic functions with potential implications in various biological processes and drug metabolism.

Cocaine esterase; Carboxylesterase 2; CE-2; CES2; ICE

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 50 mM NaAc, 150 mM NaCl, 10% Glycerol, pH 5.5. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.