protein

Alpha 1-Microglobulin Protein, Rat (HEK293, His)

HY-P76169

5 μg;10 μg;50 μg;100 μg

40;70;200;340 USD

Alpha 1-Microglobulin Protein, Rat (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

40;70;200;340 USD

Alpha 1-microglobulin (called bikunin) plays multiple roles: maintaining extracellular matrix and cell membrane structure, acting as an antioxidant at the blood-placenta interface, maintaining mitochondrial redox homeostasis, and protecting renal tubular cells from heme induction of oxidative damage.It acts as a serine protease inhibitor and contributes to extracellular space remodeling, cell adhesion and cumulus expansion during ovulation.Alpha 1-Microglobulin Protein, Rat (HEK293, His) is the recombinant rat-derived Alpha 1-Microglobulin protein, expressed by HEK293 , with C-His labeled tag.

Rat

Bikunin is involved in maintaining the structure and function of the extracellular matrix and cell membranes. It acts as an antioxidant by reducing oxidized collagen fibers and preventing oxidative damage at the blood-placenta interface. It also helps maintain mitochondrial redox homeostasis by scavenging free radicals and preserving ATP synthesis. Bikunin protects renal tubule epithelial cells from heme-induced oxidative damage to mitochondria. It has a chaperone role in facilitating the correct folding of bikunin itself in the endoplasmic reticulum. Bikunin is a serine protease inhibitor and plays a role in extracellular space remodeling and cell adhesion. It inhibits various proteases involved in inflammation and cytotoxic responses. Bikunin is also involved in the transfer of heavy chains from the I-alpha-I complex to hyaluronan, allowing for the remodeling of extracellular matrix proteoglycan structures. Additionally, it plays a role in cumulus oophorus expansion during ovulation and inhibits calcium oxalate crystallization.

Alpha-1-microglobulin; Protein HC; ITI-LC; Bikunin; AMBP

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.