protein

ANP32A Protein, Human (His)

HY-P76150

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

45;72;190;300;840;1430 USD

ANP32A Protein, Human (His)

proteins

E. coli

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

45;72;190;300;840;1430 USD

The multifunctional ANP32A protein regulates multiple cellular processes, including tumor suppression, apoptosis, cell cycle progression, and transcription. It promotes apoptosis by activating caspase-9 and supporting apoptotic body formation. ANP32A Protein, Human (His-GST) is the recombinant human-derived ANP32A protein, expressed by E. coli , with N-His, N-GST labeled tag. The total length of ANP32A Protein, Human (His) is 237 a.a., with molecular weight of ~28 KDa.

Human

The ANP32A protein emerges as a multifunctional regulator involved in diverse cellular processes, encompassing tumor suppression, apoptosis, cell cycle progression, and transcription. Functionally versatile, it promotes apoptosis by facilitating the activation of caspase-9 (CASP9) and supporting apoptosome formation. Additionally, ANP32A contributes to the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. It exerts inhibitory control over EP300/CREBBP and EP300/CREBBP-associated factor by histone masking, preferentially binding to unmodified histone H3 and impeding its acetylation and phosphorylation, leading to cell growth inhibition. Beyond chromatin dynamics, ANP32A participates in various biochemical processes, including the regulation of mRNA nuclear-to-cytoplasmic translocation and stability through its association with ELAVL1 (Hu-antigen R). The protein also plays a role in E4F1-mediated transcriptional repression and inhibits protein phosphatase 2A. Notably, ANP32A is indispensable for influenza A, B, and C viral genome replication, mediating the assembly of viral replicase asymmetric dimers and playing a crucial role in foamy virus mRNA export from the nucleus. This versatile functionality underscores the integral role of ANP32A in orchestrating multiple cellular pathways.

Acidic leucine-rich nuclear phosphoprotein 32 family member A; pp32; LANP; Mapmodulin; C15orf1; MAPM; PHAP1

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.22 μm filtered solution of 50 mM Tris-HCL, 300 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.