protein

SMPD1 Protein, Mouse (sf9, His)

HY-P76134

10 μg;50 μg;100 μg

115;300;480 USD

SMPD1 Protein, Mouse (sf9, His)

proteins

Sf9 insect cells

10 μg;50 μg;100 μg

115;300;480 USD

The SMPD1 protein converts sphingomyelin to ceramide through two enzymatic forms, one targeted to endolysosomes and the other released extracellularly.Lysosomal exocytosis becomes a significant source of the secretory form during stress responses.SMPD1 also exports cholesterol from intraendolysosomal membranes and exhibits phospholipase C activities.Its role in stress-induced apoptosis modulation is mediated through ceramide production.SMPD1 Protein, Mouse (sf9, His) is the recombinant mouse-derived SMPD1 protein, expressed by Sf9 insect cells , with C-His labeled tag.

Mouse

The SMPD1 protein functions by converting sphingomyelin into ceramide through two enzymatic forms derived from alternative trafficking of a single precursor protein. One form is targeted to the endolysosomal compartment, while the other is released extracellularly. However, during stress responses, lysosomal exocytosis may serve as a significant source of the secretory form. Within lysosomes, it carries out the conversion of sphingomyelin to ceramide and plays a crucial role in exporting cholesterol from intraendolysosomal membranes. Additionally, SMPD1 exhibits phospholipase C activities towards 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Its involvement in stress-induced apoptosis modulation is mediated through ceramide production.

Sphingomyelin phosphodiesterase; Acid sphingomyelinase; ASMase; Smpd1; Asm

Greater than 85% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 8.0, 0.1% Tween20.

Shipping with dry ice