protein

VLDLR Protein, Human (HEK293, His)

HY-P76125

5 μg;10 μg;50 μg;100 μg

52;88;220;350 USD

VLDLR Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

52;88;220;350 USD

The VLDLR protein is a multifunctional receptor that mediates energy metabolism by binding VLDL and transporting it into cells. It interacts with Reelin/RELN, APOE-containing ligands and clusterin/CLU. VLDLR Protein, Human (HEK293, His) is the recombinant human-derived VLDLR protein, expressed by HEK293 , with C-His labeled tag. The total length of VLDLR Protein, Human (HEK293, His) is 770 a.a., with molecular weight (glycosylation form) of 110-130 kDa.

Human

VLDLR protein, a multifunctional cell surface receptor, plays a pivotal role in energy metabolism by binding to VLDL and facilitating its endocytic transport into cells. Beyond lipid transport, VLDLR exhibits versatile binding capabilities, interacting with a diverse array of molecules, including Reelin/RELN, apolipoprotein E/APOE-containing ligands, and clusterin/CLU. In its inactive state, VLDLR forms homooligomers or heterooligomers with LRP8. Upon ligand binding, homooligomers undergo rearrangement into higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling pathways by binding to DAB1. This interaction triggers the phosphorylation of DAB1, orchestrating the cellular responses necessary for the accurate positioning of newly generated neurons. Subsequently, VLDLR acts as a stop signal for migrating neurons, preventing their entry into the marginal zone. Notably, in the context of microbial infection, VLDLR serves as a receptor for Semliki Forest virus.

Very low-density lipoprotein receptor; VLDL-R

Greater than 95% as determined by Tris-Bis PAGE

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.